WHAT COULD GO WRONG? –
Nov. 8, 2023 – We analyzed six randomized controlled trials representing 259 patients with moderate to severe PTSD. In all trials, about half were injected with ketamine. The rest received either salt water or the drug midazolam, a benzodiazepine like Xanax that is also used as an anesthetic agent.
Patients receiving ketamine saw their PTSD symptoms reduced by about 25% both at one day and one week after therapy. But if patients received repeated injections over four weeks, PTSD symptoms declined by only 12%. Reduction of depression symptoms were more modest but still significant.