AND IT’S FUN –
May 8, 2026 – Psilocybin recipients had a higher percentage of cocaine-abstinent day. Psilocybin recipients had a greater likelihood of complete cocaine abstinence. CUD affects millions of people worldwide, with an estimated 25 million individuals reporting use in 2025. According to Hendricks, the hypothesis was formulated considering previous studies that have shown anti-addictive effectiveness of psilocybin in smoking cessation and alcohol use disorder.
Participants were randomized to receive a single oral dose of psilocybin, 25 milligrams per 70 kilograms of body weight, or an active placebo. Participants also received cognitive behavioral therapy one month before and after an all-day investigational drug treatment session. Thirty-six participants completed the assessment 180 days after the end of the treatment, which included follow-back interviews and urinalysis to verify reports of abstinence.
