Brain Implant for Depression Is About to Be Tested in Humans - Addiction/Recovery eBulletin

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April 27, 2026 – The latest brain-computer interface could help people recover from severe depression. Motif Neurotech announced Monday that the US Food and Drug Administration has approved a human study to trial the company’s blueberry-sized brain implant that sits in the skull and delivers electrical stimulation to treat depression. The company’s device is implanted in the skull just above the dura, the brain’s protective membrane. It targets the central executive network, a part of the brain that is responsible for high-level cognitive functions and is underactive in major depressive disorder. The implant emits specific patterns of stimulation to turn “on” this network.

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