Nov. 21, 2022 – A team from the University of California recruited 277 participants with moderate to severe osteoarthritis in their knee and who had taken NSAIDs for at least a year.

They also analyzed data on 793 participants who suffered from the condition but did not take the medication.

All had MRI scans of the affected knee at the start of the study and again after four years, with images analyzed for signs of inflammation.

Results revealed there appeared to be no long-term benefit of taking NSAIDs.

Joint inflammation and the quality of knee cartilage at the start of the study were worse in the participants taking NSAIDs compared to the other group, and had deteriorated more at the four-year follow-up.

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