New Drug for Mitigation of Cannabis Withdrawal Symptoms  - Addiction/Recovery eBulletin

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Feb. 14, 2025 – The CDC reports that among individuals who use cannabis, approximately 3 in 10 have cannabis use disorder. The risk of developing cannabis use disorder is even higher for individuals who begin to use the drug before the age of 18. Though it is federally illegal, dozens of states and the District of Columbia have legalized cannabis at the state level, heightening use of the drug nationwide and across multiple age groups. In 2021 alone, 52.5 million people, or about 19% of Americans, used cannabis at least once.

Critically, there are currently no FDA-approved medications for the treatment of either cannabis use disorder or cannabis withdrawal symptoms, making further research into potential therapies such as PP-01 paramount as cannabis use increases across the country.

“We recognize that many people do use cannabis without becoming dependent, but as with alcohol, some may develop a dependence (use disorder) that may be sustained and worsened by withdrawal symptoms,” Constantine continued. “Our mission is to provide a treatment option for those who want help discontinuing cannabis.”

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