Oct. 6, 2022 – The authors then assessed the association between antidepressant use and four different morbidities: diabetes, hypertension, coronary heart disease (CHD), and cerebrovascular disease (CV), and two different mortality outcomes, including cardiovascular disease (CVD) and all-cause mortality. Each morbidity was then assessed utilizing Cox’s proportional hazard model (a regression model commonly used to understand the association between the survival time of patients and one or more predictor variables).

The authors highlight that the experience of the symptoms commonly understood as “depression” is strongly associated with “health risk behaviors” or “cofounders,” such as obesity, smoking, and lack of physical activity, which are also risk factors for both CVD and diabetes. Through multiple statistical analyses, Bansal and colleagues did their best to account for these risk factors.