March 26, 2024 – LSD is still illegal, but recent studies show that this powerful compound is not usually dangerous if taken under controlled circumstances and that it has the potential to help some people with serious mental conditions. The FDA recently designated a form of LSD as a breakthrough therapy to treat generalized anxiety disorder. This decision was based partly on a rigorously designed drug trial in which about half of the patients on the drug got significant relief from the condition.

The FDA’s breakthrough therapy designation speeds up the development and review of drugs intended to treat a serious condition where early evidence indicates the drug may be better than available therapies. The acceleration of this process may well lead to FDA approval of LSD for treating generalized anxiety disorder within the next few years. That approval would automatically legalize the clinical use of LSD.