NO PEA BRAIN JOKES –
April 23, 2025 – Major scientific discoveries can arise from simple decisions: say, by simply looking where virtually no one else has. Such was the case for Ines Ibañez-Tallon, a research associate professor at The Rockefeller University, who over the past decade has revealed how one small, understudied region of the brain plays an outsized role in addiction and substance abuse—work that’s sparked a federally funded search for new medications that may help people beat chemical dependencies.
Known as the habenula, this narrow strip of gray and white matter—so tiny it’s considered a microstructure—is an ancient piece of the brain, first appearing in vertebrates about 360 million years ago. Digging deep into this little node, Ibañez-Tallon uncovered an extremely complex and highly connected command center—one that’s part finely tuned sensor and part lightning-fast switchboard, detecting and sending chemical signals to other brain regions, including those that produce pleasure-inducing and modulatory neurotransmitters such as dopamine, acetylcholine, serotonin, and norepinephrine. She’s also documented that the habenula helps regulate emotional states and cognitive behaviors, including motivation, disappointment, depression, and stress.
