Jan. 20, 2120 – Standard behavioral treatment for meth addiction typically involves highly structured group therapy, Volkow explained. Another option is a rewards-based motivational therapy, involving monetary incentives, although this controversial approach is largely deployed outside the United States. The study was led by Dr. Madhukar Trivedi, a professor of psychiatry at UT Southwestern Medical Center in Dallas. All participants were outpatients seeking to get their addiction under control at one of several treatment clinics across the country. The study unfolded in two stages over three months. In the first stage, patients (aged 18 to 65) were divided into two groups. One was given the combination therapy, which involved a shot of naltrexone every three weeks along with a daily dose of bupropion. The other group was given placebo shots and pills. 

Urine drug screening was conducted four times in each stage. Those in the placebo group who saw no improvement by week six were rolled over into the second stage, and then randomly reassigned to either a new treatment group or another placebo group. 

Success was defined as three clean drug screenings out of four.



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